Proto-oncogene abnormalities and their relationship to tumorigenicity in some human glioblastomas.

Abstract

Human glioblastomas are highly malignant intracranial tumors, some of which demonstrate amplification of the epidermal growth factor-receptor (EGF-R) gene. Overexpression of this gene is seen in the majority of primary tumors; however, the role of the EGF-R gene in glial tumorigenesis is unknown. The authors explored the relationship between EGF-R gene… (More)

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Cite this paper

@article{U1989ProtooncogeneAA, title={Proto-oncogene abnormalities and their relationship to tumorigenicity in some human glioblastomas.}, author={Hoi Sang U and Pamela Kelley and James D. Hatton and J Y Shew}, journal={Journal of neurosurgery}, year={1989}, volume={71 1}, pages={83-90} }