Prothymosin alpha enhances human and murine MHC class II surface antigen expression and messenger RNA accumulation.

@article{Baxevanis1992ProthymosinAE,
  title={Prothymosin alpha enhances human and murine MHC class II surface antigen expression and messenger RNA accumulation.},
  author={Constantin N. Baxevanis and Dimitris Thanos and G J Reclos and E Anastasopoulos and George C Tsokos and Joseph D. Papamatheakis and Michael Papamichail},
  journal={Journal of immunology},
  year={1992},
  volume={148 7},
  pages={1979-84}
}
Prothymosin alpha (ProT alpha) is an acidic polypeptide with potentiating effects on HLA-DR-restricted in vitro cellular immune response systems such as T cell proliferative responses to soluble proteins and cellular auto- or alloantigens. Experiments were performed to investigate the effect of ProT alpha on MHC class II Ag expression in human monocytes, murine splenocytes, and tumor cell lines at both protein and molecular levels. RIA and immunofluorescence analysis revealed that ProT alpha… CONTINUE READING

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Moreover , ProT alpha was shown to induce HLA - DR Ag expression in a priori HLA - DR - negative tumor cells .
Moreover , ProT alpha was shown to induce HLA - DR Ag expression in a priori HLA - DR - negative tumor cells .
The enhancing effect of ProT alpha was demonstrated convincingly using precultured human peripheral monocytes , which are known to express decreased amounts of surface HLA - DR Ag , and HLA - DR - positive human cell lines .
Moreover , ProT alpha was shown to induce HLA - DR Ag expression in a priori HLA - DR - negative tumor cells .
Moreover , ProT alpha was shown to induce HLA - DR Ag expression in a priori HLA - DR - negative tumor cells .
The enhancing effect of ProT alpha was demonstrated convincingly using precultured human peripheral monocytes , which are known to express decreased amounts of surface HLA - DR Ag , and HLA - DR - positive human cell lines .
Moreover , ProT alpha was shown to induce HLA - DR Ag expression in a priori HLA - DR - negative tumor cells .
Moreover , ProT alpha was shown to induce HLA - DR Ag expression in a priori HLA - DR - negative tumor cells .
The enhancing effect of ProT alpha was demonstrated convincingly using precultured human peripheral monocytes , which are known to express decreased amounts of surface HLA - DR Ag , and HLA - DR - positive human cell lines .
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