• Biology, Medicine
  • Published in Journal of immunology 1983

Prothymocytes in postirradiation regenerating rat thymuses: a model for studying early stages in T cell differentiation.

@article{Castellanos1983ProthymocytesIP,
  title={Prothymocytes in postirradiation regenerating rat thymuses: a model for studying early stages in T cell differentiation.},
  author={R. Cano Castellanos and R Leizerovitz and Nurit Kaiser and N Galili and Aaron Polliack and A Korkesh and Uri Galili},
  journal={Journal of immunology},
  year={1983},
  volume={130 1},
  pages={
          121-9
        }
}
Prothymocytes were obtained from regenerating thymuses of intrathymic-irradiated, bone marrow-shielded rats. In contrast to cortical thymocytes, which are small nondividing cells containing nuclear TdT, prothymocytes are characterized by their large size, high mitotic activity, lack of natural attachment, absence of PNA-binding capacity, nonexpression of membranal thymic specific antigens, and absence of nuclear TdT. In addition, these cells are capable of responding to the mitogens Con-A and… CONTINUE READING