Prothrombolytic action of normobaric oxygen given alone or in combination with recombinant tissue-plasminogen activator in a rat model of thromboembolic stroke.

@article{David2012ProthrombolyticAO,
  title={Prothrombolytic action of normobaric oxygen given alone or in combination with recombinant tissue-plasminogen activator in a rat model of thromboembolic stroke.},
  author={H{\'e}l{\`e}ne N. David and Benoit Haelewyn and Mickael Degoulet and Denis G. Colomb and Jean Jacques Risso and Jacques H Abraini},
  journal={Journal of applied physiology},
  year={2012},
  volume={112 12},
  pages={2068-76}
}
The potential benefit of 100 vol% normobaric oxygen (NBO) for the treatment of acute ischemic stroke patients is still a matter of debate. To advance this critical question, we studied the effects of intraischemic normobaric oxygen alone or in combination with recombinant tissue-plasminogen activator (rtPA) on cerebral blood flow and ischemic brain damage and swelling in a clinically relevant rat model of thromboembolic stroke. We show that NBO provides neuroprotection by achieving cerebral… CONTINUE READING
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