Prothrombin Synthesis and Degradation in Rat Hepatoma ( H-35 ) Cells : Effects of Warfarin

  • W. J.
  • Published 2000
Vitamin K is a substrate for the enzyme catalyzing the carboxylation of specific glutamyl residues to y-carboxyglutamy1 residues in hepatic precursors of a limited number of plasma proteins, including prothrombin. The y-carboxylation of these proteins can be blocked by the anticoagulant warfarin; and in the bovine and human, warfarin treatment results in… (More)