Prothracarcin, a novel antitumor antibiotic.

  title={Prothracarcin, a novel antitumor antibiotic.},
  author={Kihachiro Shimizu and Isao Kawamoto and Fusao Tomita and Makoto Morimoto and Koichi Fujimoto},
  journal={The Journal of antibiotics},
  volume={35 8},
A novel antibiotic, prothracarcin was isolated from the culture broth of Streptomyces umbrosus subsp. raffinophilus DO-62. The antibiotic has the molecular formula of C14H14N2O and belongs to the pyrrolo [1,4]benzodiazepine antibiotics. Its structure has been elucidated by mass and NMR spectra. It is active against Gram-positive and Gram-negative bacteria and experimental murine tumor sarcoma 180 and leukemia P388. 


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