Proteus in the world of proteins: conformational changes in protein kinases.

@article{Rabiller2010ProteusIT,
  title={Proteus in the world of proteins: conformational changes in protein kinases.},
  author={Matthias Rabiller and Matthaeus Getlik and Sabine Kl{\"u}ter and Andr{\'e} Richters and Sandra T{\"u}ckmantel and Jeffrey R. Simard and Daniel Rauh},
  journal={Archiv der Pharmazie},
  year={2010},
  volume={343 4},
  pages={193-206}
}
The 512 protein kinases encoded by the human genome are a prime example of nature's ability to create diversity by introducing variations to a highly conserved theme. The activity of each kinase domain is controlled by layers of regulatory mechanisms involving different combinations of post-translational modifications, intramolecular contacts, and intermolecular interactions. Ultimately, they all achieve their effect by favoring particular conformations that promote or prevent the kinase domain… CONTINUE READING

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