Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

@inproceedings{Lim2015ProteotoxicSI,
  title={Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates},
  author={Junghyun Lim and Martin Lenard Lachenmayer and Shuai Wu and Wenchao Liu and Mondira Kundu and Rong Wang and M. Asaliaru Komatsu and Young Joo Oh and Yanxiang Zhao and Zhenyu Yue},
  booktitle={PLoS genetics},
  year={2015}
}
Disruption of proteostasis, or protein homeostasis, is often associated with aberrant accumulation of misfolded proteins or protein aggregates. Autophagy offers protection to cells by removing toxic protein aggregates and injured organelles in response to proteotoxic stress. However, the exact mechanism whereby autophagy recognizes and degrades misfolded or aggregated proteins has yet to be elucidated. Mounting evidence demonstrates the selectivity of autophagy, which is mediated through… CONTINUE READING
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