Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles.

Abstract

Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein… (More)
DOI: 10.1016/j.febslet.2011.11.022

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Cite this paper

@article{Simon2012ProteostasisOT, title={Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles.}, author={Di{\'a}na Simon and Esther Garc{\'i}a-Garc{\'i}a and Felix Royo and Juan Manuel Falc{\'o}n-P{\'e}rez and Jes{\'u}s {\'A}vila}, journal={FEBS letters}, year={2012}, volume={586 1}, pages={47-54} }