Proteopedia entry: Coiled‐coil structure of keratins

@article{Hanukoglu2014ProteopediaEC,
  title={Proteopedia entry: Coiled‐coil structure of keratins},
  author={Israel Hanukoglu and Liora Ezra},
  journal={Biochemistry and Molecular Biology Education},
  year={2014},
  volume={42}
}
Type I and type II keratins represent a large family of proteins that are encoded by 54 genes in the human genome. Matched pairs of these keratins form heterodimers that constitute the basic building blocks of cytoskeletal intermediate filaments and epidermal derivatives of hair, nail and horn. Keratins have an important place in the history of the elucidation of protein structure as in 1951, Pauling et al. suggested the first model for a-helix structure for wool a-keratins, in the absence of… Expand
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References

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The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins
TLDR
The amino and carboxy termini of the Type II keratin are very different from those of microfibrillar keratins and other nonkeratin IF proteins, however, they contain unusual glycine-rich tandem repeats similar to the amino terminus of the type I keratin. Expand
The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins
TLDR
The DNA sequence of a cloned cDNA that is complementary to the mRNA for the 50 kilodalton (kd) human epidermal keratin is determined, providing the first amino acid sequence for a cytoskeletal keratin. Expand
Structural basis for heteromeric assembly and perinuclear organization of keratin filaments
TLDR
It is shown that K14-Cys367 impacts nuclear shape in cultured keratinocytes and that mouse epidermal keratinocyte lacking K14 show aberrations in nuclear structure, highlighting a new function for keratin filaments. Expand
The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain.
TLDR
This work has used information about interatomic distances, bond angles, and other configurational parameters to construct two reasonable hydrogen-bonded helical configurations for the polypeptide chain; it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of syntheticpolypeptides. Expand
New currency for old rope: from coiled-coil assemblies to α-helical barrels.
TLDR
Complexs above pentamer are interesting because they are barrel-like, having central channels or pores with well-defined dimensions and chemistry, leading to intriguing new structures, and possibilities for functionalisation and applications. Expand