Proteopedia entry: Coiled‐coil structure of keratins

  title={Proteopedia entry: Coiled‐coil structure of keratins},
  author={Israel Hanukoglu and Liora Ezra},
  journal={Biochemistry and Molecular Biology Education},
Type I and type II keratins represent a large family of proteins that are encoded by 54 genes in the human genome. Matched pairs of these keratins form heterodimers that constitute the basic building blocks of cytoskeletal intermediate filaments and epidermal derivatives of hair, nail and horn. Keratins have an important place in the history of the elucidation of protein structure as in 1951, Pauling et al. suggested the first model for a-helix structure for wool a-keratins, in the absence of… Expand
Epidermolysis bullosa simplex–generalized severe type due to keratin 5 p.Glu477Lys mutation: Genotype‐phenotype correlation and in silico modeling analysis
This work describes six patients with a keratin 5 mutation resulting in a glutamic acid to lysine substitution at position 477 who have a distinctive, severe and sometimes fatal phenotype and performs in silico modeling to show protein structural changes resulting in instability. Expand
Detection of endogenous lipids in chicken feathers distinct from preen gland constituents
The results indicate that endogenous lipids are detectable in chicken feathers and distinct from UGS and in analogy to the morphogenesis of the cornified envelope of chicken feather lipids that may have derived from cellular feather-precursors, apparently enduring the specific cell death during developmental feather cornification. Expand
Draft Genome Sequence of Chryseobacterium sp. Strain P1-3, a Keratinolytic Bacterium Isolated from Poultry Waste
The 4.6-Mbp draft genome sequence of the keratinolytic bacterium with a G+C content of 37.0% and 4,087 protein-coding genes is reported, isolated from poultry waste. Expand
Complete genome sequence of a keratin-degrading bacterium Chryseobacterium gallinarum strain DSM 27622(T) isolated from chicken.
The 4633,632bp complete genome sequence of the strain DSM 27622(T) with 4161 genes is reported, which shows a keratin-degrading bacterium belonging to the class Flavobacteriia, which was isolated from chicken. Expand
Effect of feather meal as proteic feeder on combi-CLEAs preparation for grape juice clarification
Abstract This work describes the preparation of combi-CLEAs of pectinases using feather meal as novel proteic feeder. Initially, four solvents were tested as precipitant agents, and ethanol wasExpand
Electric field modulation of light energy transmission along intermediate filaments isolated from porcine retina
Abstract Presently we report new experimental method for simultaneous measurements of electrical and optical properties in vitro for the intermediate filaments (IFs) in the axial direction,Expand


The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins
The amino and carboxy termini of the Type II keratin are very different from those of microfibrillar keratins and other nonkeratin IF proteins, however, they contain unusual glycine-rich tandem repeats similar to the amino terminus of the type I keratin. Expand
The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins
The DNA sequence of a cloned cDNA that is complementary to the mRNA for the 50 kilodalton (kd) human epidermal keratin is determined, providing the first amino acid sequence for a cytoskeletal keratin. Expand
Structural basis for heteromeric assembly and perinuclear organization of keratin filaments
It is shown that K14-Cys367 impacts nuclear shape in cultured keratinocytes and that mouse epidermal keratinocyte lacking K14 show aberrations in nuclear structure, highlighting a new function for keratin filaments. Expand
The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain.
This work has used information about interatomic distances, bond angles, and other configurational parameters to construct two reasonable hydrogen-bonded helical configurations for the polypeptide chain; it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of syntheticpolypeptides. Expand
New currency for old rope: from coiled-coil assemblies to α-helical barrels.
Complexs above pentamer are interesting because they are barrel-like, having central channels or pores with well-defined dimensions and chemistry, leading to intriguing new structures, and possibilities for functionalisation and applications. Expand