Proteomics of the radioresistant phenotype in head-and-neck cancer: Gp96 as a novel prediction marker and sensitizing target for radiotherapy.

@article{Lin2010ProteomicsOT,
  title={Proteomics of the radioresistant phenotype in head-and-neck cancer: Gp96 as a novel prediction marker and sensitizing target for radiotherapy.},
  author={Ting-Yang Lin and Joseph Tung-Chien Chang and H M Wang and S. T. Chan and Chi-Ching Chiu and Chien-Yu Lin and Kang-Hsing Fan and Chun-ta Liao and I Chen and Tsan Zon Liu and Hsiao-Fang Li and A Cheng},
  journal={International journal of radiation oncology, biology, physics},
  year={2010},
  volume={78 1},
  pages={246-56}
}
PURPOSE Radiotherapy is an integral part of the treatment modality for head-neck cancer (HNC), but in some cases the disease is radioresistant. We designed this study to identify molecules that may be involved in this resistance. METHODS AND MATERIALS Two radioresistant sublines were established by fractionated irradiation of the HNC cell lines, to determine differentially proteins between parental and radioresistant cells. Proteomic analysis and reverse-transcription polymerase chain… CONTINUE READING

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