Proteomics of the corpus callosum unravel pivotal players in the dysfunction of cell signaling, structure, and myelination in schizophrenia brains

@article{SaiaCereda2015ProteomicsOT,
  title={Proteomics of the corpus callosum unravel pivotal players in the dysfunction of cell signaling, structure, and myelination in schizophrenia brains},
  author={Ver{\^o}nica M. Saia-Cereda and Juliana Silva Cassoli and Andrea Schmitt and Peter Falkai and Juliana Mendes do Nascimento and Daniel Martins-de-Souza},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2015},
  volume={265},
  pages={601-612}
}
Schizophrenia is an incurable and debilitating mental disorder that may affect up to 1 % of the world population. Morphological, electrophysiological, and neurophysiological studies suggest that the corpus callosum (CC), which is the largest portion of white matter in the human brain and responsible for inter-hemispheric communication, is altered in schizophrenia patients. Here, we employed mass spectrometry-based proteomics to investigate the molecular underpinnings of schizophrenia. Brain… CONTINUE READING
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