Proteomics of muscle chronological ageing in post-menopausal women

  title={Proteomics of muscle chronological ageing in post-menopausal women},
  author={Marine Gueugneau and C{\'e}cile Coudy-Gandilhon and Oph{\'e}lie Gourbeyre and Christophe Chambon and Lydie Combaret and C{\'e}cile Polge and Daniel Taillandier and Didier Attaix and Bertrand Friguet and Andrea B. Maier and Gillian Butler-Browne and Daniel M B{\'e}chet},
  booktitle={BMC Genomics},
Muscle ageing contributes to both loss of functional autonomy and increased morbidity. Muscle atrophy accelerates after 50 years of age, but the mechanisms involved are complex and likely result from the alteration of a variety of interrelated functions. In order to better understand the molecular mechanisms underlying muscle chronological ageing in human, we have undertaken a top-down differential proteomic approach to identify novel biomarkers after the fifth decade of age. Muscle samples… CONTINUE READING
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