Proteomics of Pancreatic Cancer

@article{Grntzdrffer2008ProteomicsOP,
  title={Proteomics of Pancreatic Cancer},
  author={Ilona Gr{\"a}ntzd{\"o}rffer and Stacy Carl-McGrath and Matthias P. A. Ebert and Christoph R{\"o}cken},
  journal={Pancreas},
  year={2008},
  volume={36},
  pages={329-336}
}
Pancreatic cancer is a devastating disease, with a mortality rate almost identical with its incidence. Late diagnosis and limited therapeutic options make early detection of pancreatic cancer a pressing clinical problem. In this context, the investigation of the pancreatic cancer proteome has recently gained considerable attention because profiles of proteins may be able to more accurately identify disease states, such as cancer. Recent pancreatic cancer proteome studies may be categorized into… Expand
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  • P. Kaur, K. Sheikh, +4 authors B. Kallakury
  • Biology, Computer Science
  • 2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  • 2010
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References

SHOWING 1-10 OF 43 REFERENCES
Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape.
TLDR
This study is the first application of isotope-coded affinity tag technology for proteomic analysis of human cancer tissue and has shown the value of this technology in identifying differentially expressed proteins in cancer. Expand
Diagnosis of pancreatic cancer using serum proteomic profiling.
TLDR
The results suggest that high-throughput proteomics profiling has the capacity to provide new biomarkers for the early detection and diagnosis of pancreatic cancer. Expand
Comprehensive proteomic analysis of human pancreatic juice.
TLDR
A comprehensive characterization of the "pancreatic juice proteome" in patients with pancreatic adenocarcinoma was carried out, and a novel protein that is 85% identical to HIP/PAP was identified, which is designated as PAP-2. Expand
Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue
TLDR
One of them, fascin, was detected in 13 out of 21 carcinoma and negative in all normal pancreas samples, and fascin expression was related to the differentiation of pancreatic carcinoma. Expand
Pancreatic adenocarcinoma—Genetic portrait from chromosomes to microarrays
TLDR
The results from various genome‐wide screening efforts, from traditional chromosome analyses to modern DNA microarray studies, are discussed, highlighting multiple potential chromosomal regions that may harbor novel cancer genes involved in the molecular pathogenesis of this lethal disorder. Expand
Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients.
TLDR
The plasma of patients undergoing surgical resection is surveyed to identify proteins which change in abundance after complete resection of pancreas tumor and these proteins are identified which correlate with post-surgical rapid recurrence of disease. Expand
Identification of Potential Markers for the Detection of Pancreatic Cancer Through Comparative Serum Protein Expression Profiling
TLDR
PCa is associated with a specific decrease of distinct serum proteins, which allows a reliable differentiation between pancreatic cancer and healthy controls. Expand
Possible detection of pancreatic cancer by plasma protein profiling.
TLDR
Although a multi-institutional large-scale study will be necessary to confirm clinical significance, the biomarker set identified in this study may be applicable to using plasma samples to diagnose pancreatic cancer. Expand
Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples.
TLDR
Large-scale proteomics analysis combining two-dimensional gel electrophoresis and mass spectrometry successfully identified 154 potential serum markers for pancreatic cancer, including fibrinogen gamma, a protein associated with the hypercoagulable state of pancreaticcancer, which discriminated cancer from normal sera. Expand
Proteomic classification of pancreatic adenocarcinoma tissue using protein chip technology.
TLDR
A number of protein panels that can distinguish effectively between pancreatic adenocarcinoma, benign, and adjacent pancreatic tissue are discovered by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. Expand
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5
...