Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages.

@article{Ichibangase2008ProteomicsOC,
  title={Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages.},
  author={Tomoko Ichibangase and Hiroshi Saimaru and Norio Takamura and Tomoki Kuwahara and Akihiko Koyama and Takeshi Iwatsubo and Kazuhiro Imai},
  journal={Biomedical chromatography : BMC},
  year={2008},
  volume={22 3},
  pages={232-4}
}
It has been known that the over-expression of alpha-synuclein, the main protein of Lewy bodies in Parkinson's disease (PD), leads to neurodegeneration in PD models. In this study, the changes in protein expression between the transgenic over-expressing human alpha-synuclein wild type (alpha-synWT) and the control Caenorhabditis elegans were elucidated by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry (FD-LC-MS/MS) proteome analysis, which is a highly selective… CONTINUE READING

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