Proteomics in diagnostic pathology: profiling and imaging proteins directly in tissue sections.

@article{Chaurand2004ProteomicsID,
  title={Proteomics in diagnostic pathology: profiling and imaging proteins directly in tissue sections.},
  author={P Chaurand and Melinda E Sanders and Roy A. Jensen and Richard M Caprioli},
  journal={The American journal of pathology},
  year={2004},
  volume={165 4},
  pages={1057-68}
}
Direct tissue profiling and imaging mass spectrometry (MS) provide a molecular assessment of numerous expressed proteins within a tissue sample. MALDI MS (matrix-assisted laser desorption ionization) analysis of thin tissue sections results in the visualization of 500 to 1000 individual protein signals in the molecular weight range from 2000 to over 200,000… CONTINUE READING