Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration.

  title={Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration.},
  author={David Butterfield and Debra Boyd-Kimball and Alessandra Castegna},
  journal={Journal of neurochemistry},
  volume={86 6},
Proteomics involves the identification of unknown proteins following their separation, often using two-dimensional electrophoresis, digestion of particular proteins of interest by trypsin, determination of the molecular weight of the resulting peptides, and database searching to make the identification of the proteins. Application of proteomics to Alzheimer's disease (AD), the major dementing disorder of the elderly, has just begun. Differences in protein expression and post-translational… CONTINUE READING


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