Proteomics identification of PGAM1 as a potential therapeutic target for urothelial bladder cancer.

@article{Peng2016ProteomicsIO,
  title={Proteomics identification of PGAM1 as a potential therapeutic target for urothelial bladder cancer.},
  author={Xingchen Peng and Fengming M Gong and Yi - Cheng Chen Ming - Chau Chang Shih - Tein Wang Wi Chen and Meng Xi Qiu and Ke Cheng and Jianying Tang and Jun Ge and Ni Chen and Hao Zeng and Ji Yong Liu},
  journal={Journal of proteomics},
  year={2016},
  volume={132},
  pages={85-92}
}
Urothelial bladder cancer (UBC) is a major global health problem. There have been no major advances for the treatment of UBC in the last 30 years. In this study, we attempted to discover novel candidate therapeutic biomarkers for UBC. We utilized a two-dimensional polyacrylamide gel electrophoresis (2-DE) and ESI-Q-TOF MS/MS-based proteomic method to compare and identify differentially expressed proteins in UBC and adjacent normal tissues. Thirty five differentially expressed proteins (over 2… CONTINUE READING