Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.

@article{MoriIwamoto2007ProteomicsFH,
  title={Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.},
  author={Sayaka Mori-Iwamoto and Yasuhiro Kuramitsu and Shomei Ryozawa and Kuniko Mikuria and Masanori Fujimoto and Shin-ichiro Maehara and Yoshihiro Maehara and Kiwamu Okita and Kazuyuki Nakamura and Isao Sakaida},
  journal={International journal of oncology},
  year={2007},
  volume={31 6},
  pages={1345-50}
}
Pancreatic cancer remains a devastating disease and >96% of patients with pancreatic cancer do not survive for more than 5 years. Gemcitabine (2'-deoxy-2'-difluoro-deoxycytidine: Gemzar) appears to be the only clinically effective drug for pancreatic cancer, but it has little impact on outcome. Proteomic analysis of gemcitabine-sensitive cells (KLM1) and resistant pancreatic cells (KLM1-R) was performed to identify target proteins of the gemcitabine. We found seven proteins, HSP27… CONTINUE READING

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