Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer.

@article{Naour2001ProteomicsbasedIO,
  title={Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer.},
  author={François le Naour and David E. Misek and Melissa Krause and Laurent Deneux and Thomas J. Giordano and Suzy Scholl and Samir M Hanash},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 11},
  pages={3328-35}
}
PURPOSE We used a proteomics-based approach to identify tumor proteins that elicit a humoral response in breast carcinoma and that may occur as circulating antigens. EXPERIMENTAL DESIGN The breast cell line SUM-44 was used as a source of tumor cell proteins for two-dimensional PAGE (2-D PAGE) and for Western blot analysis in which individual sera were analyzed for primary antibodies. RESULTS Sera from 30 newly diagnosed patients with breast cancer were screened for IgG antibodies to tumor… CONTINUE READING

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