Proteomics and transcriptome approaches to investigate the mechanism of human sex determination.

@article{Sato2009ProteomicsAT,
  title={Proteomics and transcriptome approaches to investigate the mechanism of human sex determination.},
  author={Youichi Sato and Toshikatsu Shinka and Gang Chen and Hong-tao Yan and Kozue Sakamoto and Ashraf Abd-elazeem Ewis and Hiroyuki Aburatani and Yutaka Nakahori},
  journal={Cell biology international},
  year={2009},
  volume={33 8},
  pages={839-47}
}
The SRY gene (sex-determining region on the Y chromosome) was isolated in 1990 and is known as the testis-determining factor on the Y chromosome. The SRY has been considered as a transcription factor since it contains an HMG box, which functions as a DNA-binding domain. However, a direct target for SRY remains to be identified. We have investigated the function of SRY through proteomics and transcriptome approaches, and by using two stable SRY-overexpressing cell lines (SRY1 and SRY2) in NT2/D1… CONTINUE READING

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