Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2

@inproceedings{Pimienta2015ProteomicsAT,
  title={Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2},
  author={Genaro Pimienta and Victor Fok and Maria Haslip and M{\'a}ria Nagy and Seyedtaghi Takyar and J. A. Steitz and Luwen Zhang},
  booktitle={PloS one},
  year={2015}
}
In Epstein-Barr virus (EBV) latent infection, the EBV-encoded RNAs EBER1 and EBER2 accumulate in the host cell nucleus to ~10(6) copies. While the expression of EBERs in cell lines is associated with transformation, a mechanistic explanation of their roles in EBV latency remains elusive. To identify EBER-specific gene expression features, we compared the proteome and mRNA transcriptome from BJAB cells (an EBV-negative B lymphoma cell line) stably transfected with an empty plasmid or with one… CONTINUE READING
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