Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis.

@article{Poon2006ProteomicsAP,
  title={Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis.},
  author={Hung Fai Poon and Holly M Shepherd and Tanea T Reed and Vittorio Calabrese and Anna-Maria Giuffrida Stella and Giovanni Pennisi and Jian Cai and William M. Pierce and Jon B. Klein and David Butterfield},
  journal={Neurobiology of aging},
  year={2006},
  volume={27 7},
  pages={1020-34}
}
Age-related impairment of functionality of the central nervous system (CNS) is associated with increased susceptibility to develop many neurodegenerative diseases. Increased oxidative stress in the CNS of aged animals is manifested by increased protein oxidation, which is believed to contribute to the age-related learning and memory deficits. Glutamate dysregulation, mitochondrial dysfunction and impaired protein synthesis are observed in aged brains, along with increased protein oxidation… CONTINUE READING
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