Proteomics analysis of serum from mutant mice reveals lysosomal proteins selectively transported by each of the two mannose 6-phosphate receptors.

@article{Qian2008ProteomicsAO,
  title={Proteomics analysis of serum from mutant mice reveals lysosomal proteins selectively transported by each of the two mannose 6-phosphate receptors.},
  author={Meiqian Qian and David E Sleat and Haiyan Zheng and Dirk Moore and Peter Lobel},
  journal={Molecular & cellular proteomics : MCP},
  year={2008},
  volume={7 1},
  pages={58-70}
}
Most mammalian cells contain two types of mannose 6-phosphate (Man-6-P) receptors (MPRs): the 300 kDa cation-independent (CI) MPR and 46 kDa cation-dependent (CD) MPR. The two MPRs have overlapping function in intracellular targeting of newly synthesized lysosomal proteins, but both are required for efficient targeting. Despite extensive investigation, the relative roles and specialized functions of each MPR in targeting of specific proteins remain questions of fundamental interest. One… CONTINUE READING

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