Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

@article{BarallobreBarreiro2012ProteomicsAO,
  title={Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.},
  author={Javier Barallobre-Barreiro and Athanasios Didangelos and Friedrich Albert Schoendube and Ignat Drozdov and Xiaoke Yin and Mariana Fern{\'a}ndez-Caggiano and Peter Willeit and Valentina O Puntmann and Guillermo Aldama-L{\'o}pez and Ajay M Shah and Nieves Dom{\'e}nech and Manuel Mayr},
  journal={Circulation},
  year={2012},
  volume={125 6},
  pages={
          789-802
        }
}
BACKGROUND After myocardial ischemia, extracellular matrix (ECM) deposition occurs at the site of the focal injury and at the border region. METHODS AND RESULTS We have applied a novel proteomic method for the analysis of ECM in cardiovascular tissues to a porcine model of ischemia/reperfusion injury. ECM proteins were sequentially extracted and identified by liquid chromatography tandem mass spectrometry. For the first time, ECM proteins such as cartilage intermediate layer protein 1… CONTINUE READING

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