Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models.

  title={Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models.},
  author={Xiaodong Cheng and Travis W. Young and Fang C. Mei},
  journal={Frontiers in bioscience : a journal and virtual library},
Using a genetically defined human ovarian cancer model, we have analyzed the protein expression profile of human ovarian cancer cells established by oncogenic RAS transformation. Cells were immortalized by retroviral transfection of SV40 t/T antigens and the catalytic subunit of telomerase (hTERT). Careful analyses of protein targets associated with oncogenic transformation have enabled us to identify several novel signaling pathways that play important roles in oncogenic transformation of… 

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