Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia

@inproceedings{Ihnatko2013ProteomicPO,
  title={Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia},
  author={Robert Ihnatko and Cora Luiza Ara{\'u}jo Post and Andreas Blomqvist},
  booktitle={British Journal of Cancer},
  year={2013}
}
Background:Anorexia-cachexia is a common and severe cancer-related complication but the underlying mechanisms are largely unknown. Here, using a mouse model for tumour-induced anorexia-cachexia, we screened for proteins that are differentially expressed in the hypothalamus, the brain’s metabolic control centre.Methods:The hypothalamus of tumour-bearing mice with implanted methylcholanthrene-induced sarcoma (MCG 101) displaying anorexia and their sham-implanted pair-fed or free-fed littermates… CONTINUE READING

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