Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain

@article{Li2008ProteomicPO,
  title={Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain},
  author={Xuefeng Li and Huijun Wang and Pingming Qiu and Hong Luo},
  journal={Neurochemistry International},
  year={2008},
  volume={52},
  pages={256-264}
}
It is well documented that methamphetamine (MA) can cause obvious damage to the brain, but the exact mechanism is still unknown. In the present study, proteomic methods of two-dimensional gel electrophoresis in combination with mass spectrometry analysis were used to identify global protein profiles associated with MA-induced neurotoxicity. For the first time, 30 protein spots have been found differentially expressed in different regions of rat brain, including 14 in striatum, 12 in hippocampus… CONTINUE READING
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