Proteomic profiling of human bone marrow mesenchymal stem cells under shear stress

  title={Proteomic profiling of human bone marrow mesenchymal stem cells under shear stress},
  author={Wei Yi and Yang Sun and Xufeng Wei and Chunhu Gu and Xiaochao Dong and Xiaojun Kang and Shuzhong Guo and Kefeng Dou},
  journal={Molecular and Cellular Biochemistry},
Mesenchymal stem cells (MSCs) are promising seed cells for tissue engineering of blood vessels. As seed cells, MSCs must endure blood fluid shear stress after transplantation. It has been shown that fluid shear stress can regulate the proliferation and differentiation of MSCs. However, the effects of fluid shear stress on MSCs including the types of proteins modulated are still not well understood. In this study, we exposed human mesenchymal stem cells (HMSCs) to 3 dyn/cm2 shear stress for 6 h… CONTINUE READING

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