Proteomic profile of carbonylated proteins in rat liver: discovering possible mechanisms for tetracycline-induced steatosis.

@article{Deng2015ProteomicPO,
  title={Proteomic profile of carbonylated proteins in rat liver: discovering possible mechanisms for tetracycline-induced steatosis.},
  author={Zhenglu Deng and Siyu Yan and Hui Hu and Zhigui Duan and Lanxuan Yin and Shenke Liao and Yubai Sun and Da-zhong Yin and Guolin Li},
  journal={Proteomics},
  year={2015},
  volume={15 1},
  pages={148-59}
}
To investigate biochemical mechanisms for the tetracycline-induced steatosis in rats, targeted proteins of oxidative modification were profiled. The results showed that tetracycline induced lipid accumulation, oxidative stress, and cell viability decline in HepG2 cells only under the circumstances of palmitic acid overload. Tetracycline administration in… CONTINUE READING