Proteomic identification of novel cytoskeletal proteins associated with TbPLK , an essential regulator of cell morphogenesis in Trypanosoma brucei

  • Michael R. McAllastera, Kyojiro N. Ikedab, +8 authors Christopher L. de Graffenrieda
  • Published 2015

Abstract

Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is highly polarized, including a single flagellum that is nucleated at the posterior of the cell and adhered along the cell surface. These features are essential and must be… (More)

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