Proteomic identification of interactions between histones and plasma proteins: implications for cytoprotection.

@article{Pemberton2010ProteomicIO,
  title={Proteomic identification of interactions between histones and plasma proteins: implications for cytoprotection.},
  author={Alan David Pemberton and Jeremy K. Brown and Neil F. Inglis},
  journal={Proteomics},
  year={2010},
  volume={10 7},
  pages={1484-93}
}
Extracellular histones released from cells during acute inflammation contribute to organ failure and death in a mouse model of sepsis, and histones are known to exert in vitro cytotoxicity in the absence of serum. Since addition of histones to serum and plasma is known to induce protein aggregation, we reasoned that plasma proteins may afford protection… CONTINUE READING