Proteomic identification of carbonylated proteins and their oxidation sites.

@article{Madian2010ProteomicIO,
  title={Proteomic identification of carbonylated proteins and their oxidation sites.},
  author={Ashraf G. Madian and Fred E. Regnier},
  journal={Journal of proteome research},
  year={2010},
  volume={9 8},
  pages={
          3766-80
        }
}
Excessive oxidative stress leaves a protein carbonylation fingerprint in biological systems. Carbonylation is an irreversible post-translational modification (PTM) that often leads to the loss of protein function and can be a component of multiple diseases. Protein carbonyl groups can be generated directly (by amino acids oxidation and the alpha-amidation pathway) or indirectly by forming adducts with lipid peroxidation products or glycation and advanced glycation end-products. Studies of… CONTINUE READING
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