Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells.

@article{Yoo2009ProteomicIO,
  title={Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells.},
  author={Dong Ryeol Yoo and Yun Ho Jang and Yeong Keul Jeon and Ju Yeon Kim and Won Bae Jeon and Yeon Joo Choi and Myeong Jin Nam},
  journal={Cancer letters},
  year={2009},
  volume={282 1},
  pages={
          48-54
        }
}
Luteolin has been shown to exhibit anti-cancer activity against several forms of cancers, including human hepatic cancers. Many in vitro studies have reported anti-oxidant effects of luteolin. Here, we demonstrate using ROS (reactive oxygen species) detection in the human hepatocellular carcinoma cell line, Huh-7, that anti-cancer action of luteolin are mediated through an increasing in intracellular ROS levels. To identify proteins potentially involved in this mechanism, a two-dimensional… CONTINUE READING
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