Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma

@article{Gou2011ProteomicIO,
  title={Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma},
  author={Lantu Gou and Wei Wang and Ai-ping Tong and Yuqin Yao and Yan Zhou and Cheng Yi and Jinliang Yang},
  journal={Journal of Molecular Medicine},
  year={2011},
  volume={89},
  pages={817-827}
}
Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world, and there is an urgent need to discover novel factors that can act as biomarkers for prognostic assessment and therapeutic targets of HCC. In this study, highly purified plasma membrane proteins from clinical tissue samples were obtained using a strategy combining sucrose density gradient centrifugation and subsequent phase partition. Using a two-dimensional gel electrophoresis and MALDI-Q-TOF MS/MS-based… CONTINUE READING
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