Proteomic dissection of the von Hippel-Lindau (VHL) interactome.

  title={Proteomic dissection of the von Hippel-Lindau (VHL) interactome.},
  author={Yanlai Lai and Meihua Song and Kevin W. Hakala and Susan T. Weintraub and Yuzuru Shiio},
  journal={Journal of proteome research},
  volume={10 11},
The von Hippel-Lindau (VHL) tumor suppressor gene encodes a component of a ubiquitin ligase complex containing elongin B, elongin C, cullin 2, and Rbx1, which acts as a negative regulator of hypoxia inducible factor (HIF). VHL ubiquitinates and degrades the alpha subunits of HIF, and this is proposed to suppress tumorigenesis and tumor angiogenesis. Several… CONTINUE READING