Proteomic discovery of protease substrates.

  title={Proteomic discovery of protease substrates.},
  author={Oliver Schilling and Christopher M. Overall},
  journal={Current opinion in chemical biology},
  volume={11 1},
Elucidation of in vivo substrate degradomes of a protease is a daunting endeavor because of the large number of proteins in a proteome and often minute and transient amounts of key substrates. Proteomic substrate screens for proteases are currently experiencing impressive progress. Mass spectrometry-based global proteome analysis, interfaced with liquid-chromatography and together with stable isotope labeling strategies, has provided increased coverage and sensitivity for quantitative… CONTINUE READING


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