Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells.

@article{VercoutterEdouart2001ProteomicDO,
  title={Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells.},
  author={Anne-Sophie Vercoutter-Edouart and Xavier Czeszak and Michel Cr{\'e}pin and J{\'e}r{\^o}me Lemoine and B{\'e}noni Boilly and Xuefen Le Bourhis and Jean Phillipe Peyrat and Hubert Hondermarck},
  journal={Experimental cell research},
  year={2001},
  volume={262 1},
  pages={59-68}
}
Fibroblast growth factor-2 (FGF-2) is a potent regulator of breast cancer cell growth through stimulation of tyrosine kinase receptors and activation of the mitogen-activated protein kinase cascade. In the present study, we have investigated changes in protein synthesis induced by FGF-2 stimulation of the prototypic human breast cancer cell line MCF-7. Using high-resolution two-dimensional electrophoresis of (35)S amino acid metabolically labeled proteins and computerized analysis of 2D… CONTINUE READING

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