Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery.

@article{Celis2004ProteomicCO,
  title={Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery.},
  author={J. E. Celis and Pavel Gromov and Teresa Cabez{\'o}n and Jos{\'e} M A Moreira and Noona S Ambartsumian and Kerstin Sandelin and Fritz Rank and Irina Gromova},
  journal={Molecular & cellular proteomics : MCP},
  year={2004},
  volume={3 4},
  pages={327-44}
}
Clinical cancer proteomics aims at the identification of markers for early detection and predictive purposes, as well as to provide novel targets for drug discovery and therapeutic intervention. Proteomics-based analysis of traditional sources of biomarkers, such as serum, plasma, or tissue lyzates, has resulted in a wealth of information and the finding of several potential tumor biomarkers. However, many of these markers have shown limited usefulness in a clinical setting, underscoring the… CONTINUE READING

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