Proteomic changes in the heart of diet-induced pre-diabetic mice.

@article{CruzTopete2011ProteomicCI,
  title={Proteomic changes in the heart of diet-induced pre-diabetic mice.},
  author={Diana Cruz-Topete and Edward O. List and Shigeru Okada and Bruce Kelder and John J. Kopchick},
  journal={Journal of proteomics},
  year={2011},
  volume={74 5},
  pages={
          716-27
        }
}
The development of type 2 diabetes (T2D) is strongly associated with obesity. In humans, T2D increases the risk for end organ complications. Among these, heart disease has been ranked as the leading cause of death. We used a proteomic methodology to test the hypothesis that a pre-diabetic state generated by high-fat diet leads to changes in proteins related to heart function and structure. Over 300 protein spots were resolved by two-dimensional gel electrophoresis (2-DE). Fifteen protein spots… CONTINUE READING
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