Proteomic biomarker discovery: it's more than just mass spectrometry.

@article{Blonder2011ProteomicBD,
  title={Proteomic biomarker discovery: it's more than just mass spectrometry.},
  author={Josip Blonder and Haleem J. Issaq and Timothy D. Veenstra},
  journal={Electrophoresis},
  year={2011},
  volume={32 13},
  pages={1541-8}
}
The previous decade witnessed an enormous number of studies with the singular goal of identifying protein biomarkers for diseases such as cancer. A large majority of these studies have focused on comparative studies of serum or plasma obtained from disease-affected and control patients. In these studies, proteins identified in the samples using MS were compared with the hope that differences between samples would reveal useful biomarkers. Unfortunately, finding clinically relevant biomarkers… CONTINUE READING

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