Proteomic assessment of the acute phase of dystrophin deficiency in mdx mice

@article{GardanSalmon2011ProteomicAO,
  title={Proteomic assessment of the acute phase of dystrophin deficiency in mdx mice},
  author={Delphine Gardan-Salmon and J Michael J Dixon and Steven Lonergan and Joshua T Selsby},
  journal={European Journal of Applied Physiology},
  year={2011},
  volume={111},
  pages={2763-2773}
}
Duchenne muscular dystrophy (DMD) is caused by the absence of a functional dystrophin protein and is modeled by the mdx mouse. The mdx mouse suffers an early necrotic bout in the hind limb muscles lasting from approximately 4 to 7 weeks. The purpose of this investigation was to determine the extent to which dystrophin deficiency changed the proteome very early in the disease process. In order to accomplish this, proteins from gastrocnemius from 6-week-old C57 (n = 6) and mdx (n = 6) mice were… CONTINUE READING

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