Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways.

@article{Chen2011ProteomicAT,
  title={Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways.},
  author={Nian-Gu Chen and Chi-Cheng Lu and Yu-Hsin Lin and Wu-Chung Shen and Cheng-Hung Lai and Yung-Jen Ho and Jing-Gung Chung and Tsai-Hsiu Lin and Yung-Chang Lin and J. Yang},
  journal={Oncology reports},
  year={2011},
  volume={26 4},
  pages={939-47}
}
Epigallocatechin-3-gallate (EGCG), a polyphenol constituent present in green tea, has been shown to inhibit the growth of cancer cells in vitro and in vivo. However, studies regarding human bladder carcinoma cells are limited and not well investigated. Hence, our study focused on the evaluation of EGCG-triggered apoptosis in TSGH-8301 human urinary bladder carcinoma cells in vivo and in vitro as well as its related molecular mechanisms. In an in vivo study, EGCG inhibited xenograft tumor size… CONTINUE READING

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through activation of FADD , caspase - 8 and the mitochondrial death pathway

  • L DeMartino, G Marfe, M Longo
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