Proteomic approaches to identify biomarkers predictive of radiotherapy outcomes

  title={Proteomic approaches to identify biomarkers predictive of radiotherapy outcomes},
  author={J{\'e}r{\^o}me Lacombe and David Azria and Alain Mang{\'e} and J{\'e}r{\^o}me Solassol},
  journal={Expert Review of Proteomics},
  pages={33 - 42}
To be highly successful, a radiotherapeutic dose must be sufficiently large to destroy radioresistant tumors, yet avoid injuring the surrounding healthy tissue. However, many patients exhibit high radiosensitivity and may develop radiation-induced early and late side effects. Because the identification of these radiosensitive patients remains largely problematic, general radiotherapy protocols currently limit the dose given, which risks delivering an insufficient dose to a significant number of… 
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