Proteomic and ultrastructural analysis of the effect of a new nitazoxanide-N-methyl-1H-benzimidazole hybrid against Giardia intestinalis.

Abstract

In an effort to develop alternative drugs for the treatment of giardiasis our research group has synthesized and evaluated a novel nitazoxanide and N-methyl-1H-benzimidazole hybrid molecule, named CMC-20. It showed an IC50 of 0.010 μM on Giardia intestinalis, lower than the IC50 values of 0.015, 0.037 and 1.224 μM for nitazoxanide, albendazole and… (More)
DOI: 10.1016/j.rvsc.2016.02.006

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Cite this paper

@article{MatadamasMartnez2016ProteomicAU, title={Proteomic and ultrastructural analysis of the effect of a new nitazoxanide-N-methyl-1H-benzimidazole hybrid against Giardia intestinalis.}, author={F{\'e}lix Matadamas-Mart{\'i}nez and Rafael Castillo and Alicia Hern{\'a}ndez-Campos and Carlos A M{\'e}ndez-Cuesta and Wanderley de Souza and Ana Paula Rocha Gadelha and Benjam{\'i}n Nogueda-Torres and Jos{\'e} Manuel Hern{\'a}ndez and Lili{\'a}n Y{\'e}pez-Mul{\'i}a}, journal={Research in veterinary science}, year={2016}, volume={105}, pages={171-9} }