Proteomic and transcriptomic profiling of Staphylococcus aureus surface LPXTG-proteins: correlation with agr genotypes and adherence phenotypes.

@article{Ythier2012ProteomicAT,
  title={Proteomic and transcriptomic profiling of Staphylococcus aureus surface LPXTG-proteins: correlation with agr genotypes and adherence phenotypes.},
  author={Mathilde Ythier and Gr{\'e}gory Resch and Patrice Waridel and Alexandre Panchaud and Aur{\'e}lie Gfeller and Paul Anthony Majcherczyk and Manfredo Quadroni and Philippe Moreillon},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 11},
  pages={1123-39}
}
Staphylococcus aureus infections involve numerous adhesins and toxins, which expression depends on complex regulatory networks. Adhesins include a family of surface proteins covalently attached to the peptidoglycan via a conserved LPXTG motif. Here we determined the protein and mRNA expression of LPXTG-proteins of S. aureus Newman in time-course experiments, and their relation to fibrinogen adherence in vitro. Experiments were performed with mutants in the global accessory-gene regulator (agr… CONTINUE READING

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Mass spectrometry as a rapid and powerful alternative to antibodies for detecting LPXTG wall-associated proteins of Staphylococcus aureus

  • A. Panchaud, E. Widmer, M. Kussmann, P. Moreillon, M. Affolter
  • Int. J. Mass Spectrom
  • 2007
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