Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells.

Abstract

Multiple myeloma (MM) is an incurable plasma cell malignancy with a terminal phase marked by increased proliferation and resistance to therapy. Arsenic trioxide (ATO), an antitumor agent with a multifaceted mechanism of action, displayed clinical activity in patients with late-stage multiple myeloma. However, the precise mechanism(s) of action of ATO has… (More)
DOI: 10.1021/pr9001004

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Cite this paper

@article{Ge2009ProteomicAF, title={Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells.}, author={Feng Ge and Xin-peng Lu and Hui-lan Zeng and Quan-Yuan He and Sheng Xiong and Lin Jin and Qing-Yu He}, journal={Journal of proteome research}, year={2009}, volume={8 6}, pages={3006-19} }