Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.

@article{Riedl2009ProteomicAU,
  title={Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.},
  author={Maureen S. Riedl and Patrick D. Braun and Kelley F. Kitto and Samuel A. Roiko and Lorraine B Anderson and Christopher N Honda and Carolyn A. Fairbanks and Lucy Vulchanova},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 42},
  pages={13377-88}
}
Peripheral tissue injury is associated with changes in protein expression in sensory neurons that may contribute to abnormal nociceptive processing. We used cultured dorsal root ganglion (DRG) neurons as a model of axotomized neurons to investigate early changes in protein expression after nerve injury. Comparing protein levels immediately after DRG dissociation and 24 h later by proteomic differential expression analysis, we found a substantial increase in the levels of the neurotrophin… CONTINUE READING

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