Proteomic analysis to dissect mitoxantrone resistance-associated proteins in a squamous lung carcinoma.

Abstract

BACKGROUND Mitoxantrone resistance has been related to the expression of a drug efflux pump breast cancer resistance pump (BCRP) but little is known of the intracellular protein changes. In this work, differential protein expression in a squamous lung carcinoma cell line, DLKP, and its mitoxantrone-resistant variant (DLKP-Mitox) was investigated to… (More)

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