Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells

@inproceedings{Zhou2016ProteomicAR,
  title={Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells},
  author={Tong Zhou and Luke N Erber and Bing Liu and Yankun Gao and Hai-Bin Ruan and Yue Chen},
  booktitle={Oncotarget},
  year={2016}
}
Proline hydroxylation is a critical cellular mechanism regulating oxygen-response pathways in tumor initiation and progression. Yet, its substrate diversity and functions remain largely unknown. Here, we report a system-wide analysis to characterize proline hydroxylation substrates in cancer cells using an immunoaffinity-purification assisted proteomics… CONTINUE READING